It requires continuous learning and continuous growth".
In contrast, M032R1 regressed upon vemurafenib treatment and displayed continuous inhibition of outgrowth, suggesting stable disease of this specific lesion (Fig 1C).
Continuous selective pressure permits outgrowth of clones that harbor lesions that are capable of enhancing disease progression, including those that contribute to therapy resistance, metastasis and relapse.
We examined the cytoarchitectural polarization of dissociated hippocampal pyramidal neurons on guidance cues designed to promote rapid outgrowth of neurites onto continuous line features and delayed neurite outgrowth onto interrupted line features.
The outer ring of microtubules is surrounded by a membrane that is continuous with the cell membrane; ciliary outgrowth is controlled by the basal body that is located just inside the cell surface at the base of the cilium.
The dedifferentiated radial glial cells are organized into an epithelium, which seals the cut end of the stump and forms a tubular outgrowth with a central lumen continuous with that of the epineural or hyponeural canal.
TJT wishes to acknowledge and thank Dr Jim Jacobson, Acting Associate Director and Chief, Diagnostic Biomarker and Technologies Branch, Cancer Diagnosis Program, DCTD NCI (deceased) for his continuous support of the work that led to this study as an outgrowth of NCI funded UO1 studies (Director's Challenge and SPECS).
In a most generalized opinion, this process is attributed to continuous generation and accumulation of Ag ions, their recharging into metallic silver followed by formation of cloud-like layers or dendritic migration outgrowths [29 31].
It is conceivable that quiescence not only plays a pivotal role in the emergence of residual disease but also in creating a pool of tumor cells that survive continuous small molecule therapy and may hence represent the "seeds" for the outgrowth of resistant clones.
The Mann–Whitney U test was used to identify differences in baseline characteristics, bacterial outgrowth, cytokine levels and histopathological scores among groups with respect to continuous variables.
