ER expression was characterized using binary and continuous measures for ER protein, ESR1 mRNA, and a multigene luminal score (LS) that serves as a measure of estrogen signaling in breast tumors.
This probably led to the dichotomization of originally continuous measures for use as trial endpoints, such as the 1.2 improvement in DAS28.
Therefore, we conducted multivariate linear regression analyses to evaluate the relationships between prenatal PBDE concentrations (using continuous measures for ln-transformed BDEs 47, 99, 100, and 153 and dichotomous measures for BDEs 85, 154, and 183) and continuous scores on developmental tests (MDI and PDI at 12, 24, and 36 months and Full, Verbal, and Performance scores at 48 and 72 months).
All multivariate models were adjusted by categorical variables for education, body mass index (World Health Organization categories), smoke-quit-dose, vigorous physical activity, activity throughout the day, and continuous measures for vegetable intake, fruit intake, total energy intake, and age at baseline.
If it is assumed, as shown in a review [ 52], that the effect size is -0.27 for placebo control vs no treatment in trials involving continuous measures for pain, then the results of our study are highly congruent (ie, effect size for OMT vs no treatment [-0.53] = effect size for OMT vs active treatment or placebo control [-0.26] + effect size for placebo control vs no treatment [-0.27]).
The use of a continuous measure for structural distance between all pairs of proteins allows us, as described in the two accompanying papers to derive sequence/structure relationships in a more quantitative way than has previously been possible.
We also report physical activity as a continuous measure for our means, standards deviations, correlations and t-tests.
2) Cheng and Li aggregate miRanda target site scores per 3'UTR as a continuous measure for miRNA targeting, but because we evaluate all words we compute an overrepresentation score of a given word in 3'UTR sequence.
Other markers, such as PSA, involve a continuous measure for which higher values indicate a greater probability of cancer.
