The path, though not continuous, leads to the Westlands suburban hub and the Sarit Centre Mall, a "city within a city" hosting restaurants, shops and a cinema, as well as being the first establishment in the city to provide bicycle parking.
The houses of TLC trial children were cleaned up by vacuuming, mopping, minor repairing, and paint stabilization to minimize continuous lead exposure (Rogan et al. 2001).
All analyses were conducted using SAS, version 9.3 (SAS Institute Inc ., except for analyses incorporating penalized splines for the continuous lead term, which were completed using R, version 3.0.1 (R Core Team 2013).
In the SRD and MRD parts of the study, continuous lead II ECG monitoring was performed for a minimum of 4 h after dosing and QTc interval was determined from read out of the ECG machine.
Mixed-effects models, including Bayley scores at five time points, showed a significant interaction over time: highest manganese quintile × continuous lead; mental development score, β = –1.27 [95% confidence interval (CI): –2.18, –0.37]; psychomotor development score, β = –0.92 (95% CI: –1.76, –0.09).
For PDI, however, we observed a negative interaction between 24-month lead and manganese only among the subset of children with both 12- and 24-month blood samples [mixed-effects model adjusted β, manganese quintile 5 × continuous lead: subset, –0.86 (95% CI: –1.66, –0.05); total sample, 0.18 (95% CI: –0.32, 0.68)].
Diagnostic criteria for postoperative myocardial infarction were the appearance of new Q waves of more than 0.04 s and 1 mm deep, or a reduction in R waves of more than 25% in at least two continuous leads of the same vascular territory, as previously described [ 12, 13].
We also conducted analyses excluding one participant who had very low MDI and PDI scores at 24 months (scores of 50 for both), and results were similar, with the exception of a weaker effect estimate for 24-month PDI [adjusted β, manganese quintile 5 × continuous lead: excluding participant, –1.01 (95% CI: –2.32, 0.30); total sample, –1.60 (95% CI: –2.93, –0.27)].
For 24-month metal analyses, results for MDI among the subset of 267 children with both 12- and 24-month blood samples were generally consistent with results based on all 24-month samples [ n = 437; mixed-effects model adjusted β, manganese quintile 5 × continuous lead: subset of 267 children, –0.53 (95% CI: –1.41, 0.35); total sample, –0.09 (95% CI: –0.63, 0.45)].
