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Bland Altman plot (upper left panel), glucose prediction error grid (lower left panel) and Clarke error grid (right panel) Fig. 3 Rate error grid of the continuous glucose error grid analysis.
Trend accuracy was expressed using continuous glucose error grid analysis [ 6].
Trend accuracy: in the rate error grid of the continuous glucose error grid analysis, 96% of the paired values were in zone A, 3.7% were in zone B and 0.3% were in zone C. Point and trend accuracy of the tested microdialysis-based CGM are good in critically ill patients.
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Continuous glucose error-grid analysis, which assesses point and trend accuracy, showed 98.2% of readings in the A zone (clinically accurate) and 1.2% in the B zone (benign errors).
Also presented is a continuous glucose-error grid analysis (CG-EGA), an outcome metric that addresses the problem of evaluating the temporal characteristics of the continuous glucose sensor process by considering pairs of reference and sensor readings as a process in time that takes into account inherent physiologic time lags (9).
AMC Academic Medical Centerr; APACHE: Acute Physiology and Chronic Health Evaluation; BMI: body-mass index; CEG: Clarke error grid; CGM: continuous glucose monitoring; CVC: central venous catheter; IQR: interquartile range; LOS: length of stay; SAPS: Simplified Acute Physiology Score; SD: standard deviation; YSI: Yellow Springs Instrument.
It also plans to integrate with insulin pumps & CGMs (continuous glucose monitors) to continue building out its unified approach — fueled by the new funding injection.
The median error of currently available real-time continuous glucose monitors is between 10 and 16% when plasma glucose levels are between 70 and 180 mg/dL (9, 10, 26, 27).
Addressing this uncertainty would require an even larger study conducted ideally at only one site, with more diverse subjects, uninterrupted continuous glucose monitoring for months at a time, and, most important, a measurement error much lower than currently seen.
Each hour glucose value from continuous glucose monitor was compared to reference arterial glucose using the Clarke error-grid analysis (C-EGA) [ 15] and when clinically unacceptable (zone C, D, or E of C-EGA) reference glycemia was used as input for the eMPC and to recalibrate the Guardian REAL-Time.
Although Hempe et al. suggest that continuous glucose monitoring is the gold standard for measuring MG, there is still considerable error relative to that of HbA1c.
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