The superiority of the continuous drug delivery strategy is limited to drugs with short half-lives.
In our system, a transient expression system is used, and continuous drug selection is not necessary.
Continuous drug delivery offers superior effectiveness/side-effect balance in cellular state switching.
In summary we have demonstrated that continuous drug delivery at low doses is a potentially effective strategy for disease treatment.
They could change plans once a year, but "must maintain continuous drug coverage" through either H.M.O.'s, prescription drug plans or a former employer's health plan.
Bausch & Lomb is doing early stage research on a continuous drug delivery system at the back of the eye implant to combat the disease.
This calculation results in an identical drug exposure (AUC) for both the discontinuous and continuous drug delivery regimens as demonstrated in Fig. 3c.
Following continuous drug exposure, the achiral compounds were found to be cytotoxic, with IC50 values in the μM range.
Another issue is that preclinical studies on the incubation of drug craving have used rats given continuous drug access during self-administration sessions (e.g., 'Short-Access' or 'Long-Access').
In order to validate the concept that more continuous drug delivery can result in superior efficacy even with the same drug exposure, we focused on HDAC inhibitors that have been extensively examined in recent times as potential HIV reactivation agents.
However, the results for HIV reactivation (Fig. 4b) show that the improved performance of continuous drug application compared to discontinuous application (with the same drug exposure) occurs to a greater extent at shorter drug half lives.
