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As the MTD had not been reached for the noncontinuous treatment, the continuous BID dosing was initiated at 600 mg BID.
Lenvatinib was orally administered by continuous BID dosing in combination with paclitaxel (200 mg m−2) intravenously administered over 3 h followed by a 1-h infusion of carboplatin (area under the curve (AUC) 6.0 min mg ml−1) on day 1 every 3 weeks from cycle 1.
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After an arrangement with the university administration, sororities will now have open continuous bidding, meaning they could admit members throughout the year and so more women of color could be admitted.
"Continuous play," he replies.
Telatinib is safe and well tolerated up to doses of 1500 mg BID continuous dosing.
Dose escalation was stopped at 1500 mg BID continuous dosing without reaching the MTD of telatinib.
Telatinib is safe and well tolerated up to a dose of 1500 mg BID continuous dosing.
Three patients had dose reductions; all from 400 to 200 mg bid (continuous dosing) because of AEs (oesophagitis, thrombocytopenia, anaemia).
One patient at the 1500 mg BID continuous dosing level had a dose interruption due to nausea and vomiting.
Eligible patients received a single dose of AZD8055 on day 1 followed 1 week later by continuous twice-daily (BID) dosing.
Nineteen patients with advanced cancers received JNJ-26483327 continuous twice daily (BID) in escalating dose cohorts ranging from 100 to 2100 mg.
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