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Even so, there is likely a continuous association between NLR and risk of adverse oncologic outcomes.
To conclude, there is strong evidence of a continuous association between HbA1c and CVD.
We used a restricted cubic spline model to investigate the continuous association between HbA1c and risk of liver disease hospitalization.
This systematic review of prospective studies confirms a strong, continuous association between A1C and subsequent diabetes risk.
Our most important limitation was the lack of original data to model the continuous association between A1C values and incidence.
6 8 The Heart Outcomes Prevention Evaluation found a continuous association between levels of urinary ACR and cardiovascular events.
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The continuous associations between HbA1c and incidence of self-reported hypertension are shown in Fig. 1.
The Toronto Tri-Hospital Study showed continuous associations between maternal glycemia and adverse pregnancy outcomes (29).
This landmark study showed that there were continuous associations between increasing maternal glucose levels (fasting as well as at 1- and 2-hours postprandial) and birth weight.
As demonstrated by the HAPO studies, there are continuous associations between maternal glucose levels and increasing birth weight and prevalence of caesarean section [ 6, 14, 25].
To evaluate the continuous associations between each marker and diabetes risk, we used Cox proportional hazards models and restricted cubic splines (17) with knots specified at the 25th, 50th, and 75th percentiles.
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