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Transient and continuous administrations equally increased eNOS expression, implying that a short contact between hormone and cells is sufficient to trigger genomic pathways.
The csMSN group and PAC-csMSN group received continuous administrations for 3 days, and then the lung tissues were removed for pathological study.
Continuous administrations may be necessary if subjects do not become colonized.
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Pulmonary hypertension was produced in sheep by the continuous administration of the thromboxane A2-mimetic U46619.
Intravaginal rings (IVRs) are an option for continuous administration of drugs in women.
Indeed, the continuous administration of certain hormones and their synthetic analogues may show substantially different effects than expected.
Conclusion: assignment to continuous administration seems to be more effective in increasing bone density than the sequential regimen.
A long half-life and accumulation of BPU and active metabolites were observed, recommending against a continuous administration.
Kisker, O. et al. Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model.
Thus, both continuous administration of interferon and persistent elevation of interferon-stimulated genes are associated with unfavourable outcomes in chronic HIV and SIV infection.
Targeting protein levels is an option but that would require the continuous administration of a drug to keep huntingtin protein levels low.
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CEO of Professional Science Editing for Scientists @ prosciediting.com