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Another limitation is present for the TNF inhibitor continuing patients.
The persistence rate for adalimumab continuing patients was 45.20%, 48.77% for etanercept and 37.29% for infliximab.
For the continuing patients, age has a significant influence on persistence (p ≤ 0.005).
The continuing patients responded to questionnaires and had dental examinations and plaster casts made.
1,468 of these patients were TNF inhibitor naive patients and 733 were defined as TNF inhibitor continuing patients.
Mean age of the TNF inhibitor continuing patients was 55 years (±12.32) with 87% being female (Table 1).
There were no significant differences in the treatment persistence rates between adalimumab, etanercept and infliximab for TNF inhibitor naive and continuing patients.
Dosage increase occurred in 7.3% adalimumab, 1.4% etanercept, and 17.2% infliximab naive patients and 5.8%, 1.1% and 11.9% respectively in the continuing patients.
Between naive and continuing patients a significant difference in persistence could be observed (HR: 1.296, 95% CI: 1.164-1.443, p = 0.000).
For TNF inhibitor continuing patients all secured diagnoses in the baseline period (1st and 2nd quarter of 2005) were included for the analysis of patient characteristics.
For continuing patients, the persistence rate after three years was 32.88% for adalimumab, 30.95% for etanercept, and 33.90% for infliximab, respectively.
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