Exact(6)
The Continuing Outcomes Relevant to Evista (CORE) trial, designed to determine the effect of raloxifene on the incidence of invasive breast cancer, was a 4-year follow-up study to the 4-year Multiple Outcomes of Raloxifene Evaluation (MORE) osteoporosis treatment trial.
Both the Multiple Outcomes of Raloxifene Evaluation 17 and the Continuing Outcomes Relevant to Evista 18 reported a significant reduction (65%and50%0%, respectively) in breast cancer overall.
In an extension of the MORE study, women who had been on raloxifene for 4 years were offered a further 4 years of treatment – the Continuing Outcomes Relevant to Evista (CORE) study.
In the 4-year Continuing Outcomes Relevant to Evista (CORE) extension of the MORE study (n = 4,011), reduced risk of invasive breast cancer by RLX was maintained versus PBO (HR 0.41, 95% CI 0.24 to 0.71) [ 66].
With an extension of this trial for a further 4 years with breast cancer as the primary outcome in the Continuing Outcomes Relevant to Evista (CORE) trial, analysis at 8 years confirmed a 66% risk reduction for breast cancer [ 8].
The Continuing Outcomes Relevant to Evista (CORE) trial was conducted to examine the effect of 4 additional years of raloxifene therapy on the incidence of invasive breast cancer in women in MORE who agreed to continue in CORE (Martino 2004; Lippman 2006).
Similar(53)
TAVR technology and equipment are rapidly advancing, with increased utilisation of advanced MDCT imaging contributing to continuing outcome improvement and broadening of procedure applications.
Weighted mean difference (WMD) was used to summarize the effect measure for continues outcomes.
Pooled ORs with 95% CI will be calculated for dichotomous outcomes, mean differences (MDs) with 95% CI for continue outcomes.
The results of dichotomous outcomes will be reported as posterior medians of OR with 95% credible intervals (CrIs), and medians of MD with 95% CrI for continue outcomes.
It is likely to become increasingly important for individual IAPT services to understand their own patient and service/treatment characteristics associated with enhanced recovery rates, to ensure continued outcomes, funding and support, as targets for recovery increase.
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