Exact(6)
In hESC-derived erythroblasts where both ε and γ globin were active and marked by similar chromatin modifications, ε globin was immediately silenced upon transfer, whereas γ globin continued to be expressed for months, implying that different transcriptional environments were required for their continuing expression.
PCL/COL1 enabled continuing expression of integrin beta1 and CD44.
The continuing expression of this plasticity into later life allows constant adaptation of the animal's nervous system to changes in the animal's body as it grows and ages, also allowing some recovery from major injury.
Our findings also suggest that the continuing expression of OCT4 in GC in neonatal marmosets represents a slower pace of differentiation in some individual cells, rather than evidence for the persistence of a stable subpopulation of pluripotent cells beyond early neonatal life, as suggested by Albert et al. (2010).
There was continuing expression of the viral transgenes at tumor harvest, but the proportion of eYFP-positive cells was lower after the injection of Ad-GR-eYFP than after the injection of Ad-eYFP alone, which was compatible with the loss of GR-expressing cells (Fig. 3C).
Nevertheless, the fact that a knock-down of MtDxs2 also led to strongly reduced expression of many other AM-related genes already hinted that the protein might be required for AM development in general [ 40], which would demand for the early induction and continuing expression during later stages that was found by our cell-type specific expression analysis.
Similar(53)
And their immediate disappearance in the later stages of infection in resistant genotype libraries and continued expression in susceptible genotypes supports a hypothesis that continual expression of this protein may lead to mitochondrial dysfunction and subsequent cell degeneracy.
Thus, most B cell lymphomas arise from GC B cells need continued expression of BCL6 to maintain their survival (Hatzi et al., 2013; Bertolo et al., 2013).
This limited expression of Atoh1 may normally be restrained by the expression of Neurod1 and absence of Neurod1 seems to allow continued expression.
For instance, continued expression of the cdc18 replication-initiation gene might be expected to complicate recovery from replication stress by promoting refiring of origins [24].
This implies that continued expression of one isoform cannot compensate for the loss of the other, suggesting specific functional differences in human keratinocytes.
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