And just as markets optimised around railroad infrastructure after its construction (and later, around highways), they would have continued to optimise around canals and other transport modes in the absence of the railroad.
To enable biomarker analysis to continue to optimise the treatment of patients with mCRC, collection of tumour samples should be recommended for all future mCRC trials.
As this was one of the first studies on RA SMI future development and evaluation via a randomised controlled trial is necessary to continue to optimise the positive outcomes of the program.
16 Although, the process of myocardial reperfusion continues to be optimised with recent advances in PPCI technology (thrombus aspiration, novel stents), 17 antiplatelet (prasugrel, ticagrelor) 18 and antithrombotic therapy (bivalirudin), 19 there is currently no effective therapy for reducing myocardial ischaemia-reperfusion (I/R) injury per se.
Royal Mail's group property director, Martin Gafsen, said: "Royal Mail continues to seek to optimise value from sites no longer required for operational use and will consider all options as to the manner in which this is achieved".
This work underpins continued efforts to optimise recombinant MSP2 constructs for evaluation as potential vaccine candidates.
As ECMO can activate inflammation and coagulation cascades, a continuing effort to optimise biocompatibility is desirable.
At a public health level, the need to manage modifiable lifestyle factors to optimise people's wellbeing continues to be imperative.
Learning to drive energy efficiency through software is a "rabbit hole that continues to grow because we are learning how to optimise these scenarios to a greater and greater extent", Livingston said.
Medical treatment alone rarely results in cure and optimising surgery continues to be the best way to improve survival.
Biomarker research in mCRC continues to rapidly evolve and promises to further optimise outcomes via better patient selection and improved tailoring of anti-cancer treatment to the molecular profile of individual patients' tumours.
