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Treatment was continued without modification for grade 1 toxicity.
In all others, treatment was continued without modification.
Because of the improvement in the clinical status of the patient, treatment continued without modification for 18 months.
Diet and exercise interventions were to be continued without modification after randomization until the end of the follow-up period.
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They suggest four potential outcomes for pilot studies: stop; continue but modify protocol (feasible with modifications); continue without modifications but monitor closely (feasible with close monitoring); or continue without modification (feasible as is).
The first review point was reached in October 2014 and the DSMC recommended that the trial continue without modification.
Where a decision has been made to stop then there should be no carry forward of data, whereas decisions to continue without modification would allow for data carry-forward.
Our conversation continued without interruption.
"That," he continued without flinching, "was awesome".
Talks continued without him.
"Of course the projects continued without me".
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