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Intervals between fractions are determined by blood count recovery and the treatment is continued to maximum response [ 31].
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Patients could receive a maximum of six courses if static disease was seen, but if responding they could continue to maximum response plus two courses up to a maximum of 12 courses.
"Despite his many injuries, he continued to offer maximum resistance.
Optimizations were converged to a gradient RMSD below 0.05 kJ/mol or continued to a maximum of 1000 iterations, at which point there were negligible changes in RMSD gradients.
Treatment was continued to a maximum of six cycles.
The study was continued to a maximum of 95 patients (including drop outs) (see Figure 1).
In patients with tumour responses or SD, the treatment was continued to a maximum of eight cycles.
After the initial 8-week titration phase, quetiapine was continued to a maximum of an additional 40 weeks.
The schedule was given every 2 weeks for four cycles; thereafter patients with objective response continued to a maximum of eight cycles.
The assigned treatment was given for a minimum of 12 weeks (at least four cycles in the GC-arm and three cycles in the G-arm) and continued to a maximum of 48 weeks (up to 16 cycles in the GC-arm and up to 12 cycles in the G-arm), unless disease progression (PD) was evident, an intolerable adverse event occurred or the patient was required to withdraw from the study.
When the upper limit of ν in the searched parameter space was increased, the ν estimates continued to equal the maximum allowed value (i.e., ν → ∞).
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