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As noted above, this difference is unlikely to be significant in cancer-promoting terms, as recognized at the point of licensing, particularly as detailed receptor studies did not reveal any Asp-B10 insulin like continued receptor signaling (17).
Our results indicate that, in some immature brain regions, betaAR desensitization is masked by more substantial increases in the activity of signaling elements downstream from the receptors, resulting in sustained responses in the face of continued receptor stimulation.
The lack of ARM390-induced internalization correlated with continued receptor coupling to G proteins and in vivo efficacy of ARM390 at the second drug administration.
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Massard C, Fizazi K. Targeting continued androgen receptor signaling in prostate cancer.
HER2-positive metastatic breast cancer (MBC) relapsing after trastuzumab-based therapy may require continued HER2 receptor inhibition to control the disease and preserve the patients' quality-of-life.
Reports of this novel receptor continued thereafter, variously referring to it as the VIP-PACAP type II receptor [29], or PVR2 [30].
To determine if part of the nuclear pool of receptor continued to shuttle between the cytoplasm and the nucleus after ligand withdrawal, we used a live cell fluorescence loss in photobleaching (FLIP) assay.
There, he continued his opiate-receptor research, but a particular opiatelike receptor, named "sigma," began to monopolize his attention.
On the other hand, tumor cells that had the usual hormone receptors continued to multiply.
Some receptors, such as TGF-β receptor, nerve growth factor receptor and epidermal growth factor receptor continue to signal from endosomes, amplifying downstream responses before being eventually degraded 21262126
Therefore, the development of improved receptor-targeted therapies requires continued efforts to dynamically map receptor surface distributions in vascular pathologies.
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