Sentence examples for continued mutation from inspiring English sources

Then we must face the pernicious problems of genetic or epigenetic mutational heterogeneity among the cells in a single tumor and of continued mutation.

Although there are serious technological and cost hurdles to surmount and resistance and continued mutation will be a constant problem, the way is clear to rational therapy.

The incidence of HFMD will be also significantly affected by the continued mutation of the virus and increasing climate change.

To test the predictions that are based on Kimura's models for sequence evolution at independently evolving and coevolving sites under continued mutation pressure (Kimura 1980 , 1985, we calculated selective constraints at paired (Cpaired) and unpaired (Cunpaired) positions in orthologous tRNAs for all species pairs (fig. 3 a ; supplementary table S1, Supplementary Material online).

It strongly correlates with Myc expression to allow continued proliferation, mutation and cancer evolution of the affected clones.

So they decided to incorporate the curve on the back cover as well: "With every book, the curve would continue its mutation, first rotate, and after one full rotation maybe multiply, change ratio and thereby its appearance, but always staying true to itself".

The frequency and scale of HFMD outbreaks are expected to increase [ 3, 12], and threaten the health security of various nations due to continuing viral mutation [ 3], climate change [ 1, 23], and the lack of health resources and effective surveillance systems in some countries [ 3].

What is interesting about the latter simulations is that in the regime of mutational robustness, the proteins continued to accumulate mutations, and in fact accumulated mutations faster than in the regime in which mutational robustness did not evolve.

During the study period, guidelines were slightly altered for patients without a mutation in the RAS genes (ras-wild-type) from bevacizumab, capecitabine and oxaliplatin (bev-CAPOX) to cetuximab, 5-fluorouracil (5-FU; intravenous) and irinotecan (cet-FOLFIRI), while patients with a RAS mutation continued receiving bev-CAPOX.

Furthermore, the T790M mutation continued to increase in all 9 patients until progression of the disease.

The quantitative measurements demonstrated that the T790M mutation continued to increase in all 9 patients until disease progression (Fig. 1A).