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Similarly, continued accrual of the rent charge after termination of the lease because the lessee fails to return the leased property does not constitute a default charge.
I will highlight three features of this environment that may call for innovative or alternative approaches to both study design and the process of informed consent to both respect the rights of the research subject and permit the continued accrual of medical knowledge.
Continued accrual and follow-up is needed to assess long term clinical outcomes.
The criterion for continued accrual was the observation of at least one tumour response.
We support its continued accrual, and encourage existing participants and new centres to enter patients.
Given continued accrual of patients with moderate to severe head injury in the prospective database, we aim to take into account this aspect in the analysis.
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RESULTS: The trial was closed early with 31 patients because of a statistical boundary that required at least 4 (13%) patients without disease progression to continue accrual.
Any arm passing the interim analysis continues accrual to the pre-planned total of 40 patients.
I believe we should continue the follow up of the Royal Marsden trial and continue accrual and follow up of the IBIS trial.
In all, 13 responses were required in the first 23 patients to continue accrual, and 24 responses out of 37 patients were required to consider the regimen promising.
We aimed to include at least 20 subjects in each of the four TCNS stages and continued subject accrual into the study until this was accomplished.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com