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Likewise, read-through inhibitors increase the frequency at which ribosomes misinterpret stop codons, causing the ribosome to continue translation past the stop codon.
However, analysis of the pulse labeled proteins revealed that a significant fraction of the ribosomes did shift frames but failed to pass the pseudoknot structures to continue translation; the strength of the pseudoknots correlated not only with the fraction of frameshifted ribosomes but also the roadblocking effect.
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We wanted to establish funds to move preliminary, but exciting, advances to a stage where they could attract follow-on private capital and/or industrial support and to provide to our faculty a resource that would enable continued translation and development and spur entrepreneurial culture.
This is a favorable starting point for continued translation toward a therapeutic application, although future studies need to carefully review target region, vector spread and dilution with this approach.
This mutation would result in out-of-frame, continued translation into the 3′-untranslated region (p.Tyr335Glyfs*113).
This can be explained as follows: a) There is a larger amount of data available for the expression of genes at the RNA level, compared to protein level, and transcription doesn't guarantee continued translation into proteins.
He continued, "The translation of 'River Town' is one of the best in China, I have learned a lot from it and really appreciate Mr. Li Xueshun".
General Landry develops a gardening hobby; Carter learns how to play the cello; Daniel continues the translation of Asgard information in the database and develops his relationship with Vala; and Cameron Mitchell Ben Browderr) and Teal'c (Christopher Judge) exercise and train while Mitchell is growing more frustrated and angry.
Hence, continued IRES-mediated translatinitiationtion may permit cell cycle progression upon mTOR inactivation in cells in which Akt kinase activity is relatively low (Shi et al, 2005).
Plants, animals, and other eukaryotes do this via a unique part of the SRP complex that only allows the translation to continue once the translating ribosome has been brought close to the membrane.
Often infections begin with relatively few virions that release their genomes into the cell and continue with the translation of these few initial genomes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com