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Yen (2003) pointed out that the foliage and branch developments begin in the initial stage of moso bamboo and their developments will continue to the second stage.
With 2 or more responses, the subset would continue to the second stage.
Because Simon's two-stage design does not stop for early efficacy [ 1], the study would continue to the second stage.
For the remaining eight studies allowed to continue to the second stage by the Gehan stopping rules and the DESR, conclusions on Hnul were consistent between the rules.
If 13 or more responses were observed, we planned to continue to the second stage for a total of 32 patients in the analysis.
In the first stage, a total of 13 patients were included and at least four responses were required to continue to the second stage.
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By following the same rules, the scanning would continue until it cannot find any new points for a given amount of time which at that moment the program would perform a spiral search to be sure that this side of the object is finished and would continue to the third stage.
If x1> r1, the trial continues to the second stage.
Because Simon's two-stage designs do not stop for early efficacy [ 1], the study continues to the second stage.
If greater than seven responses were observed, then the trial was continued to the second stage to recruit a further 30 consecutive patients.
The evaluation of the first stage of the trial showed less than three objective responses needed to continue into the second stage of the trial and thus the trial was terminated.
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