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One patient discontinued in order to receive sunitinib on a continuation protocol (no other patients continued to receive sunitinib after study end on a continuation protocol).
Patients were treated for 28 days and entered into a continuation protocol if a serological response or clinical benefit was observed.
We prospectively assessed atorvastatin pharmacokinetics during its continuation (in accordance with the above mentioned statin continuation protocol) in nine ICU patients admitted for severe sepsis or septic shock during the year 2008 (these patients are not included in the above mentioned retrospective cohort analysis).
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An independent data monitoring committee reviewed safety data and advised on study continuation and/or protocol changes.
During continuation of protocol-defined treatment (sunitinib as per CCS or DFIS) six-weekly clinical assessments and twelve-weekly radiological assessments will occur, in line with standard practice.
Todd Stern, the US president's envoy for climate change, said the European Union was the only remaining "major player" that would potentially support a continuation of the protocol after its provisions expire in 2012.
Unfortunately, the high mortality rate of type I diabetic rats after permanent coronary artery ligation precluded further continuation of experimental protocol.
However, as we found the discharge part far more complicated to properly perform (e.g., being able to interpret all ICU protocols, continuation of high risk medication, restarting a patient's medication), we find that a pharmacist with specific ICU knowledge and understanding of the discharge process is necessary for the discharge process.
During manual searching of records, it became clear that several records of trials that were registered as interventional were in fact records of observational trials, diagnostic accuracy trials or treatment protocols for continuation of treatment after inclusion in a study protocol.
On Tuesday, Xie Zhenhua reiterated his country's support for a continuation of the Kyoto Protocol (KP).
However, the work on one strand – the continuation of the Kyoto protocol – is said to be close to completion.
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