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These data provide a strong case for continuation of maintenance treatment to beyond one year after a first episode of psychosis, but we also acknowledge that the clinical decision for maintenance treatment must be made in an individualised manner taking into consideration factors such as side effects and the availability of effective monitoring for relapse.
In this multi-center randomized controlled three-arm trial with a sample size of 276 participants an 8 session group CT with guided tapering of AD, will be compared to continuation of maintenance AD use versus the combination of CT with maintenance AD in remitted patients with recurrent MDD.
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This became important in Ms Schiavo's case because of the reasonable issues surrounding care, continuation of care, interventions versus maintenance, and most vitally, decisions to end life.
In locally advanced (arterial encasement) or metastatic disease, initial intensive therapy could be followed by omission of either oxaliplatin or irinotecan (depending on which is more problematic) for continuation of a "maintenance program," as this is strictly palliative therapy.
However, little is known about the continuation and maintenance treatment of PD.
Based on our previous experience of conducting studies of the continuation and maintenance treatment of PD [ 12, 65, 66], we predict that attrition during the RCT will not exceed 10%.
Although continuation of oral remission-maintenance therapy with aminosalicylates or steroids at constant dose may be considered a weakness of this trial, it was the only practicable way to investigate patients with acute UC proctitis and proctosigmoiditis.
The prediction in our study reflects the continuation or maintenance of an internal model of the beat.
This trial will provide clinicians with much-needed evidence to guide the continuation and maintenance treatment of one of the most disabling and lethal of psychiatric disorders.
Future population projections are based on the assumptions concerning the continuation or maintenance of such trends.
Further research on the cost-effectiveness, long-term outcomes and the role of psychotherapy in the continuation and maintenance treatment of chronically depressed patients is required to conclusively assess the value of psychotherapy as an add-on treatment to pharmacotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com