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Two different approaches have been evaluated; the so-called continuation maintenance when the maintenance agent was part of initial therapy and is continued in the absence of disease progression ("maintained") or switch maintenance when a third agent is initiated after a defined number of cycles chemotherapy in the absence of disease progression.
"During this time, pemetrexed for continuation maintenance had been included in the CDF, threatened with delisting twice, only to be included again on appeal," he said.
Two monoclonal antibodies, cetuximab and bevacizumab, are used as continuation maintenance, but the incremental benefit of the maintenance therapy with these agents is undetermined.
Phase III trials have not revealed an overall survival benefit for continuation maintenance chemotherapy, and this approach should be considered investigational.
Several phase III trials with both chemotherapeutic and targeted agents have demonstrated either PFS prolongation (continuation maintenance) or both PFS and OS benefit (switch maintenance).
As scheduled prior to inclusion in this study, the patients received treatment with carboplatin (area under the concentration-time curve of 6.0 mg/mL/min -paclitaxel (200 mg/mL/min -paclitaxel area)-bevacizumab (15 mg/kg) and continuation maintenance bevacizumab upon non-progression after 4��cycles.
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In this multi-center randomized controlled three-arm trial with a sample size of 276 participants an 8 session group CT with guided tapering of AD, will be compared to continuation of maintenance AD use versus the combination of CT with maintenance AD in remitted patients with recurrent MDD.
The identification of effective continuation and maintenance strategies for elderly patients with psychotic depression is a critical issue that has not been fully explored.
However, because of the relapse rate, the American Psychiatric Administration had to come up with three phases of treatment with medications: acute, continuation, and maintenance.
They only considered treatment with antidepressants indicated for current depression, ignoring possible continuation or maintenance treatment and other indications for the use of antidepressants like anxiety disorders.
However, little is known about the continuation and maintenance treatment of PD.
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