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Patients in the continuation group continued to receive statins.Outcomes included death within 60 days (primary outcome), survival, cardiovascular events, performance status, quality of life (QOL), symptoms, number of nonstatin medications, and cost savings.A total of 381 patients were enrolled; 189 of these were randomized to discontinue statins, and 192 were randomized to continue therapy.
In the SU continuation group, all medications were continued at their previous doses.
Two groups of septic patients were distinguished: the discontinuation group (patients in whom statins were stopped at ICU admission); and continuation group (patients in whom statins were continued whenever possible).
Few participants experienced cardiovascular events (13 in the discontinuation group vs 11 in the continuation group).
The study considered two groups: SAT DE group (patients switched from initial SAT to fluconazole or to SAT stop within five days of SAT initiation) and SAT continuation group (patient without switch or stop of the initial SAT within five days of SAT initiation).
Two subjects originally enrolled in the SU continuation group were excluded from the final analysis.
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The proportion of participants in the discontinuation vs continuation groups who died within 60 days was not significantly different (23.8% vs 20.3%9090% CI, -3.5% to 10.5%; P=.36) and did not meet the noninferiority end point.
Models for the Starter and Continuation groups were run separately, given different sample selection criteria.
Furthermore, some trials found no significant differences in outcomes between the withdrawal of the drugs and continuation groups.
For instance, in the Starter and the Continuation groups of chronic analgesic treatment, escalation of analgesics was consistently and positively associated with the use of TCA.
All individual prescriptions of analgesics were observed for each patient in both the Starter and the Continuation groups during the observation period and during the 6 months prior to the observation period.
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