The ESEC also reviewed safety data throughout the trial and was responsible for advising the study sponsor regarding treatment continuation, dose modification, and termination of the study.
Where there is possible Isoniazid induced peripheral neuropathy a therapeutic dose of Pyridoxine is given for 2 3 weeks followed by a low continuation dose.
In the intensive phase (IP) the drugs were supposed to be administered under direct observation thrice weekly, while in the continuation phase (CP), the first dose of the week was to be given under observation and the rest were self administered.
The initial oral PSL dose of 0.6 mg/kg/day, continuation of the initial dose for 2 to 4 weeks and tapering by 5 mg every 1 to 2 weeks to a maintenance dose (2.5 to 5 mg/day) over a period of 2 to 3 months are recommended.
A major finding was that most patients during the continuation phase received a weight-adjusted biweekly dose of INH below the PNTP-recommended 15-mg/kg/day dose.
The mean dose of lurasidone during the 18-month continuation study was 61.8 mg/day, and the modal dose was 60 mg/day.
As the persistence method depends on the assumption of a prescribed daily dose of 240 mg, further dose-independent measures of treatment continuation were employed.
Despite treatment for the S. stanley infection, and continuation of high dose cotrimoxazole, there remained a residual left-sided neck collection.
RNTCP uses a 3-month (36 doses) intensive phase (IP) of isoniazid, pyrazinamide, rifampicin, and ethambutol (with streptomycin for the first 24 doses), and a 5-month (66 doses) continuation phase (CP) of isoniazid, rifampicin, and ethambutol.
Sung, J. J. et al. Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial.
