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Where there is possible Isoniazid induced peripheral neuropathy a therapeutic dose of Pyridoxine is given for 2 3 weeks followed by a low continuation dose.
The ESEC also reviewed safety data throughout the trial and was responsible for advising the study sponsor regarding treatment continuation, dose modification, and termination of the study.
For older children, crystalline penicillin (60 mg/kg/6 hourly) and Chloramphenicol (loading dose 40 mg/kg and a continuation dose of 25 mg/kg/6 hourly) was used.
Bacterial infections in children ≤ 2 months were treated with a combination of Gentamicin (a loading dose of 4 mg/kg and a continuation dose of 2 mg/kg every 24 hours for babies <2 kg or a loading dose of 7 mg/kg and a continuation dose of 4 mg/kg every 24 hours for babies ≥ 2 kg) and Ampicillin (50 mg/kg/6 hrly).
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At continuation, further doses were reduced by 33%.
As the acute attack resolves it is appropriate to use low doses of oral colchicine as an adjunct to NSAID, glucocorticosteroid, or ACTH treatment, and continuation of low dose oral colchicine can help to suppress rebound flares after such treatment.
Despite treatment for the S. stanley infection, and continuation of high dose cotrimoxazole, there remained a residual left-sided neck collection.
During the continuation therapy, a dose reduction of 0.25 mg m−2 day−1 topotecan for the next cycle was recommended in the case of thrombocytopenia (platelet counts ⩽50 000 μl−1), whereas in the case of neutropenia, G-CSF should be applicated without reduction of the topotecan dosage.
RNTCP uses a 3-month (36 doses) intensive phase (IP) of isoniazid, pyrazinamide, rifampicin, and ethambutol (with streptomycin for the first 24 doses), and a 5-month (66 doses) continuation phase (CP) of isoniazid, rifampicin, and ethambutol.
Because doses of the OAD at 12 months were not provided, it is not possible to ascertain whether the significant A1C differences at that time might also be related to the continuation of submaximal doses of the SU in patients who had not achieved an A1C level of <7.0%.
The continuation of the 75 mg dose or dose up-titration to the 150 mg dose will occur in an automated process without site or patient awareness.
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