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Insofar as video games allow for less down time, I wonder whether they will yield individuals who expect continual stimulation from their environment rather than those who can draw out inventiveness from within themselves.
Many anticholinesterases, when administered in large doses, are severely toxic, achieving their effects by causing a continual stimulation of the parasympathetic nervous system.
Cocaine causes the signaling molecule dopamine to build up in the brain, resulting in continual stimulation of dopamine-sensing neurons.
Two known mechanisms of OP toxicity can contribute to this effect: 1) elevated consumption of energy because of increased muscular activity due to continual stimulation when acetylcholine is not degraded and 2) cholinergic receptor-independent mitochondrial disruption [ 28].
Further observations were made in cells following continual stimulation extending over ∼10 min. Resumption of scanning then confirmed a similar appearance of subsidiary events in RyR s/s but not WT or RyR2 p/s myocytes (Fig. 3a,c,e).
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Although delayed clearance of BCG may promote immunity by providing continual antigenic stimulation, expanding the nature of the response through enhanced processing and presentation may be a more effective strategy for host protection.
Single cell time-lapse imaging data showed persistent cycling of NF- κB localisation between the cytoplasm and nucleus of SK-N-AS cells in response to continual TNFα stimulation [ 12, 13].
Continual or repeated stimulation of receptors by agonists usually leads to reduced responsiveness to further agonist challenge.
Continual or repeated agonist stimulation of GPCRs usually leads to reduced responsiveness to further agonist stimulation (25, 34), through the process of receptor desensitization, which has been shown to protect cells from the adverse effects of overstimulation and inappropriate GPCR signal transduction.
They also suggest that reports of improvements after one session of tDCS – the most common report in enhancement studies – may not translate to continual improvement with additional stimulation.
Relative schemes stimulate continual improvement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com