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Alternatively, as the liver experiences continual replacement of cell populations, the cell populations with altered methylation might have been replaced by week 12 from progenitor cell pools in which DMR methylation was normal.
Biomimetic coating of bioinert alloys with calcium phosphate phases provides a good alternative to the prerequisite for the continual replacement of implants because of the failure of bone-implant integration.
Continual replacement of hypertrophic cartilage, together with establishment of secondary ossification centers at outer (epiphyseal) tissue ends, defines the cartilaginous growth plates that provide bones with longitudinal growth potential until maturity.
Rapid postnatal muscle growth in C57 Bl/6 animals is partially driven by the fusion of satellite cells to existing myofibers while in mdx animals there is a large scale degeneration-regeneration phase at 4 6 weeks of age followed by continual replacement of degenerated fibers throughout adult life.
Casas et al. (2006) have discussed that this pattern is a consequence of continual replacement of plant materials in managed in situ populations and home gardens, including the introduction of plant material from other areas to home gardens, as well as the high gene flow between populations determined by bats and birds participating in pollination and seed dispersal.
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Proliferation and differentiation are integrated and continual cell replacement processes in adult tissue homeostasis [7], [16].
This may explain why stem cells from both neonatal and adult epidermis rarely enter the cell cycle even though the epidermis requires continual cell replacement.
The process of continual cell replacement is critical for the maintenance of adult tissues and is typically maintained through the presence of stem cells.
Since the epidermis continually renews itself by sloughing a layer of cells every day, it is in a constant state of cellular turnover and requires continual cell replacement for life.
The population structure of subgroup III serogroup A meningococci seems to represent continual, sequential replacement of fit genotypes by related variants during periods of several years to decades (19 ).
There is continual destruction and continual renewal.
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