Sentence examples for continual escalation from inspiring English sources

He encouraged the party to seek out a much wider membership, and also advocated the continual escalation of violent confrontation, believing both to be necessary for the revolution to succeed.

SHAKESPEARE Continual eloquence is tedious.

As previously reported [ 1, 2, 10], about 50% of contemporary phase I trials still use the "Fibonacci series"; in our study, PK-guided dose-escalation or continual reassessement method are used in 3 and 2% of the trials, respectively.

The escalation continued.

On Saturday, the escalation continued.

Trials using the continual reassessment method of dose escalation are simulated, with a modification of the rules to allow patients to choose a higher dose if they wish.

This report documents simulation studies showing the impact that a patient choice of doses would have on the performance of a widely used Bayesian model-based dose-escalation scheme – the continual reassessment method (CRM) (O'Quigley et al, 1990).

The continual reassessment method is a recommended dose escalation design for including patients in phase I clinical trials designed to estimate the maximum tolerated dose.

Continue to seek out a continual future.

We present a Phase I dose escalation trial design based on a modified continual reassessment method that allows for sharing of information between populations.

New designs need to be more largely explored, such as accelerated titration design and continual reassessment method, which could allow more rapid dose-escalation and reduce the number of patients treated with infra-therapeutic dose-levels [14].