Cell-based studies of MDR to date have involved establishing multidrug-resistant cancer cell lines through continual or multistep drug selection and using high drug concentrations.
By the start of this year, it appeared that his competitive career was at an end: he had apparently put on two stone and told a local newspaper that he was "disgusted" with cycling after almost five years spent fighting a series of court cases and bans amid continual allegations of drug use.
Continual evolution in drug discovery from plants remains an important source of new pharmaceuticals.
Since the central nervous acting agent, tetramethylpyrazine, is reported to have appreciable blood brain barrier penetrability, a design allowing simultaneous and continual monitoring of drug concentrations in blood and brain was employed to study the distribution of intravenously administered tetramethylpyrazine (10 mg kg−1).
I was sentenced to 304 months that's 25 years and 4 months for Continual Criminal Enterprise, the drug kingpin charge they gave to Pablo Escobar and El Chapo.
Continual monitoring of drug resistance patterns is imperative.
As LPS is present only in bacterial membranes, it has been a target of continual interest to drug discovery programs aimed at developing more efficacious antibiotics.
Developmental changes are rapid during the first weeks and months of life, thus requiring continual modification of drug dosage regimens designed for treating pediatric patients.
The continual reinfection by drug-naive worms that occurs in these trial settings dilutes observable anti- Wolbachia and antifilarial effects, making it difficult to estimate therapeutic efficacy and compare different doxycycline regimens, evaluated at different times after treatment.
Factors limiting tuberculosis control include a huge burden of asymptomatic infection, the lack of a vaccine that protects from pulmonary disease, and lengthy antibiotic regimens that are being compromised by the continual emergence of drug-resistant strains (Casenghi et al, 2007; Nunes-Alves et al, 2014).
