Exact(1)
This has been the general case in the insulin detemir trials program, but statistically significant advantages in glycemic control were obtained with insulin detemir versus NPH insulin in the longest trial (in type 1 diabetes) after two years, with this trial allowing continual dose titration.
Similar(59)
However, homeopaths generally find that it is preferable to prescribe individualized homeopathic remedies to each patient to attain better long-term sustained results without having to take continual doses of any medicine (natural or otherwise).
When we compared extreme deciles of intake, subjects in the top decile had 29% (flavonols) and 28% (flavanones) reductions in risk of ovarian cancer, which suggested a continual dose-response at higher habitual intakes.
After several months of continual dosing, these tumors regain the ability to grow.
Current GD-specific treatment, enzyme replacement therapy (ERT) and substrate reduction therapy, is beneficial but not curative, and so patients usually have regular continual dosing.
Given this information, the subclinical symptoms experienced may be a reflection of the low level continual dosing occurring from amalgam fillings.
To determine the capacity of continual low-dose lysosomal enzyme infusion into the cerebrospinal fluid of mucopolysaccharidosis type IIIA (MPS IIIA) mice to reverse established neurodegenerative disease.
For example, it is tempting, and a continual practice, to dose primary cells or cell lines in vitro with very high doses without any consideration or discussion of realistic in vivo exposures; for instance, 100 μg NSPs/mL culture medium labeled as a low dose is extremely high and is unlikely to be encountered in vivo.
Trials using the continual reassessment method of dose escalation are simulated, with a modification of the rules to allow patients to choose a higher dose if they wish.
Whereas the continual increase of H2O2 dose to 118 and 177 mg ml−1 (1:2.4 and 1 3.5 w/w FeSO4:H2O2 ratio, respectively) showed 68 and 69%% disappearance of endosulfan.
[1998 Practical implementation of a modified continual reassessment method for dose-finding trials. Cancer Chemother. Pharmacol. 41, 429 436] and Whitehead and Williamson [1998.
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