Sentence examples for contiguous gene from inspiring English sources

Although large deletions involving CYBB are known to cause contiguous gene syndrome (CGS), only a few patients have been studied precisely at the molecular levels.

Our genomic analysis suggests replicative mechanisms as a predominant mechanism underlying PMP22-RAI1 contigenes gene duplications and provides further evidence supporting the role of complex genomic architecture in genomic instability.

Syndromic DSD resulting from these deletions were primarily ascribed to contiguous gene deletions.

Two other families of conserved SASP factors (the CXCL and CCL families) are also organized as contiguous gene clusters.

The genes encoding these MMPs form a contiguous gene cluster in both the mouse and human genomes.

Indeed, neighbor clustering [41] has allowed the enrichment for contiguous gene sets and the prediction of more context-related expression patterns.

Because many chromosomal syndromes are caused by more than one gene (contiguous gene syndromes), identification and characterization of additional individuals may elucidate the full etiology of this syndrome.

PWS is a contiguous gene deletion syndrome generally recognized at birth because of severe hypotonia, hypogonadism, and failure to thrive, followed by developmental delay, hyperphagic obesity, and relative growth hormone deficiency in early childhood [7].

Thus, mutant mice with a maternal deletion from Ube3a to Gabrb3 provide an AS mouse model that is molecularly more similar to the contiguous gene deletion form of AS in humans than mice with Ube3a mutation alone.

Furthermore, deletion of PKD1 and TSC2 in a contiguous gene deletion syndrome, exhibits a severe PKD phenotype [37] further suggesting that these two proteins may be involved in a common pathway.

Our extensive behavioral characterization of both maternal and paternal deletion mice supports that the maternal deletion mouse is a valid model for the contiguous gene deletion form of AS.