In contrast, CA1 network reactivation was not sensitive to the minor contextual alterations but could be affected by large input changes.
In our screen, we used contextual fear conditioning to identify genetic alterations in mice that affect remote memory.
Presidential candidates cannot change the contextual climate.
We applied an inescapable foot shock (IFS) paradigm that induces both long-lasting contextual and non-contextual anxiety [31] and alterations in emotional reactivity measured as a blunted light-enhanced startle [32].
Particularly, in the experiment involving only small contextual changes, the reactivation index in CA1 did not change accordingly, although the alteration in environmental inputs seemed to be detected by mice, as reflected by their freezing behaviors.
The deficit in contextual but not auditory fear memory suggests the possible alterations in hippocampus-related synaptic transmission and plasticity [29].
Alteration of the stimulus format, or question, to include contextual vignettes allows testing of higher cognitive levels and problem-solving ability [ 3, 8, 34].
Maternally deprived females, in contrast, had reduced number of cells in the dentate gyrus with alterations in the dendritic arrangement, but neurogenesis, LTP, spatial learning, and contextual fear conditioning were not affected.
We report that ablation of Rgs7 results in alterations of GABABR-GIRK signaling, disrupts synaptic plasticity in the hippocampus, and impairs contextual learning and memory.
However, the principal causes of this dysfunction and the specific contribution of endosomal alterations herein are still debated, owing to the high complexity and the strong contextual dependence of AD pathogenesis.
