In contrast, in embryonic stem cells there is abundant methylation in non-CpG contexts, comprising approximately 25% of the total number of methylcytosines detected [ 3].
While these entities themselves have already been found to be cancer relevant, our network demonstrates their putative regulatory contexts comprising their coordinating partners and their targets, and such information may shed additional light on tumorigenesis mechanisms.
Visuospatial contexts comprise a key element in the formation of place fields.
Between them, the processes of differentiation combined with convergence, the differences between rich and poor, and the role of the socioeconomic and cultural contexts, comprise a "convergence-divergence model" of dietary change, rather than a simple transition.
We also hypothesized that an entrepreneurial context comprising personal knowledge about other entrepreneurs and territorial location in a given region would influence perceived entrepreneurial ability.
During angiogenesis, mural cells are recruited to sprouting endothelial cells and define a stabilizing context, comprising cell-cell contacts, secreted growth factors and extracellular matrix components, that drives vessel maturation and resistance to anti-angiogenic therapeutics.
Mural cells define a context comprising heterotypic cell-cell contacts, ECM deposition and soluble factors that inhibits endothelial proliferation, maintains capillary diameter, regulates blood flow and provides survival signals [7].
In a second part, we focused on a metapopulation context comprising more than two patches and relatively small population sizes, without making the assumption of constant proportion of susceptibles over time.
The Helicobacter outer membrane porin (Hop) class of factors plays an important role in this context, comprising several well-described proteins including BabA, SabA, AlpA/B, OipA, HopI, HopQ, and HopZ [ 4, 15, 16].
Interrogating the bases either side of each substitution to give a trinucleotide sequence context comprising 96 possible combinations followed by non-negative matrix factorization, the authors were able to decompose the spectrum of sequence contexts into five signatures ('signatures A-eacheach believed to represent the scar of a distinct mutational process [ 1].
She'd prefer to embody certain ideas than to have to verbalize them, when the context comprises dubious, inherited, unexamined assumptions about gender, sexuality, songwriting, and celebrity.
