Others have focused on the role of both in the broader political and economic context, and found that these broader conditions make coercive offers a live possibility.
We then mutated the three critical tyrosines (Tyr232, 253 or 257) individually to glutamic acid, which mimics phosphorylation, in the BCR63-ABLKD context and found that each Y/E substitution alone is sufficient to block the nuclear import of this kinase-defective BCR63-ABLKD protein (Figure 5B).
We then used ChIP-PED to compare TF expression and TG activity in each context and found that E TF and A TG values were significantly different between healthy and hepatitis C-infected PBMCs, with a gradual decrease in E TF and A TG values as patients recovered from infection (Supplementary Table S5, Fig. 3 and Supplementary Fig. S6).
Etchegary et al. (2013), looked at public opinions about genetics in a healthcare context in Canada, and found that participants felt they did not know enough but were open to the potential value of genetic information in their own healthcare.
In this context, we found that FBP1 strongly and independently interacts with p53 as well as with the p53-regulatory proteins, BCCIP and TCTP, and therefore may be responsible for the suppression of p53 activity in Huh7 cells.
We then analyzed the genetic context of proto-spacers and found that CRISPR can have from 1 to 8 spacers targeting proto-spacers in the same genome.
We examined our context specific TFBS prediction, and found that co-localization of multiple TFs on promoters was frequent (Table 2).
We put these three viral targets in the context of human interactome and found that Helicase_C was able to bind other 87 host domains related with cancer in 28 tissues.
In another study, Zhou et al. (2014) compared the toxicity of As2O3, NaAsO2, and monomethylarsonous acid (MMAIII) in the context of zinc finger peptides and found that MMAIII changed the conformation and displaced zinc in C2H2, C3H1, and C4 zinc finger proteins isolated from human keratinocyte HaCaT cells.
Authors also examined the splicing events in the context of protein 3D structures and found that the boundaries of alternative splicing regions generally occur in coil regions of secondary structures and exposed residues and the majority of the sequences involved in splicing are located on the surface of proteins.
