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SREBPs were dispensable for homeostatic proliferation, which indicated a context-specific requirement for SREBPs in effector responses.
This is true in DT40 chicken cells but a recent knockout in mice of CENP-U by Kagawa et al (PMID 24481920) has challenged this view as CENP-U is essential in embryonic stem cells and in embryonic development (but not in embryo-derived fibroblasts; the reasons for this context-specific requirement are not yet known).
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In this work a component model for open system is proposed, in which components encapsulate computation, systems deal with the creation and communication of components, and the rest of the context-specific requirements and concerns are implemented by first-class, reflective, reusable entities, called controllers.
Figure 2d shows that aside from two outliers that are responding to context-specific requirements, the majority of programs surveyed maintain a low CHW to beneficiary ratio.
Monitoring is also context specific: requirements during cardiac surgery will be different from those in the intensive care unit or emergency department.
This study, therefore, argues that next to general requirements: we also need to collect context-specific user requirements for open data platforms.
Thus it appears that the requirement for CBP/p300-mediated coactivation is context-specific for a variety of endogenous target genes driven by distinct transcription factors.
But the solution felt frustratingly context-specific.
But academic research is often very context-specific.
The reality is much more context-specific.
Context-specific process variants fit only one process context.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com