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Data on the primary care context were obtained from the NHS Information Centre [ 50] for each PCT area.

Domain linkages and domain context were obtained from the domain architectures using the TASS package.

At recognition time, the contexts are obtained from the decoding network.

The contexts were obtained from the hallmarks of cancer proposed by Hanahan and Weinberg [ 24].

Costs for sewerage in low- and middle-income contexts were obtained from published literature.

The NOE distance restraints and torsion angles for backbone angles δ and ε for the trimethylene cross-links in the 5′-CpG-3′ and 5′-GpC-3′ sequence contexts were obtained from the earlier NMR data (16, 17).

The genome sequences of 26 selected representative lactic acid bacteria, including the protein functional annotation and the gene contexts, were obtained from the NCBI bacterial genome database (version 15 Aug., 2008) [ 114].

Informed written consent was obtained from volunteers.

Informed consent was obtained from blood donors.

Informed written consent was obtained from relatives.

Informed consent was obtained from study participants.

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