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In this context, translational studies in clinical specimens (BAL and sputum) from patients with CF indicate that lipidated FRET reporters designed to measure protease activity at the surface of inflammatory cells, such as NEmo-2 and LaRee-1 [16] 16], may be sensitive novel tools to identify CF patients with the greatest risk to develop severe lung damage.
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This approach, in the context of translational medicine, could be more effective in the clinic than the existing administrative model of fragmentation into different disciplines.
Dr. Michael N. Liebman, Managing Director, Strategic Medicine, Inc. (PA, USA), discussed the issues of stratification and personalization in medicine within the context of translational medicine.
In the context of translational regenerative medicine, biomarkers not only characterize the function, quality, and safety/toxicity of a product (potency) but also help identify those patients or cohorts who would most likely benefit from such an innovative treatment modality (prediction or stratification) and allow efficacy in those patients who have been identified as responders to be monitored.
Gene-optimization significantly enhanced the CAI in all tested genes, a parameter often cited in the context of translational efficiency [17], [39], [48].
In the context of translational drug discovery, it may therefore be likely that effects of putative cognitive enhancers observed in the 5C-CPT would exhibit substantial cross-species predictive validity for effects in the human CPTs.
I have been thinking of these RNA stacking parameters recently in the context of translational selection.
A second important parameter that is influenced by codon context is translational accuracy.
Other studies have also considered transcript length in the context of translational efficiency and gene function [ 8, 45].
Our study provides insight into patient experiences and satisfaction in clinical trials in the context of translational retinal research.
In contrast to C. elegans, the zebrafish, also known as Danio rerio, belongs to the class of vertebrates, which is an advantage in the context of translational research.
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