Sentence examples for context of wild type from inspiring English sources

Mutation context of wild type versions of AID and APOBEC3G are shown in Figure 3 figure supplement 1. Analysis of additional yeast transformants and breast cancers is shown in Figure 3 figure supplements 2 4.

The same group of mutations, when transferred to the context of wild-type Flp, can relax its specificity to include non-native target sites.

Furthermore, whereas R177S and V198E served to improve kcat/Km 60-fold in the context of the heterodimer, the same mutations in the context of wild-type Neo had a ninefold negative effect on kcat/Km.

To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine susceptibility in Mycobacterium smegmatis, we studied the drug susceptibility pattern of various mutants with genetic alterations in the 16S rRNA decoding A-site in the context of wild-type and mutant protein S12.

bar mutants show distinct cranial vascular hemorrhages and pericardial edema in the context of wild-type body morphology.

Antigenic peptide presented in the context of Q115E HLA-A2 is recognized substantially better than in the context of wild-type HLA-A2 (Fig. 2).

Interaction plots for each gene deletion strain in both the context of wild-type YOR1 and yor1-ΔF670/R1116T expression are given in Additional Files 2 and 3.

Gene profiles selected for clustering had Yor1-ΔF interaction scores >10 or <-16, or in the context of wild-type Yor1 had gene-drug interaction >10 or <-12.

Moreover, we observed oligomycin sensitivity to be more strongly dependent on ERV14 in the context of wild-type Yor1 than Yor1-ΔF.

The recruitment defects and failure to maintain telomeres in vivo occur in the context of wild-type levels of activity, suggesting that the mutants described in this study are separation-of-function alleles that dissociate enzymatic activity from recruitment.

Together, these results indicate that the activation of MAPK signalling is still possible at the level of TOPK, even in the context of wild-type KRAS and BRAF, and is unlikely because of loss of PTEN.