Sentence examples for context of the substrates from inspiring English sources
POT1 has been shown to stimulate WRN helicase activity on forked telomeric substrates, however no effect on WRN exonuclease was reported, at least in the context of the substrates used in this study [ 22].
However, while TRF2 has been reported to either stimulate or repress WRN exonuclease activity [ 20, 21], POT1 does not appear to influence this activity, at least in the context of the substrates tested in these studies.
That all three starting proteins yielded the same Ile113 replacements strongly suggests that the system has converged and that Cys and Val are the "best" residue at this position (at least in the context of the substrates studied).
The assessment of these characteristics are not necessarily absolute values, but reflect useful, measureable performance trends [15] and therefore must also be seen within a context of the substrate and other practical on site variables.
We first investigated the subsite preferences of GlpG in the context of the TatA substrate in vitro by conducting a complete positional scanning mutagenesis of its P5 to P1 region.
We do not know the reason for this discrepancy but might be due to different assay conditions, variation during expression and purification or the sequence context of the DNA substrate.
The results also show that the enzyme is able to effectively select for high affinity and specificity for the same chemical moieties both in the context of smaller substrates, and in that of a larger reactive intermediate.
These films are intended to serve as partial mimics of the ECM in order to better understand cell adhesion responses, specifically in the context of dynamic substrates.
The microstructure and protective behavior of the coatings were characterized in the context of the elements alloyed in the substrates.
We evaluate the properties of carbon nanotubes in the context of synthetic tissue substrates and contrast them with the nanoscale features of the extracellular environment.
