The materials were designed to address cardiovascular risk and to provide a context for patients who might be presented with a series of lab values but might not have a context for the severity of the risk.
In this context, the evaluation of the severity of the illness, and/or the measurement of the outcome of treatment, could be undertaken by using an existing burnout questionnaire.
Bootstrap experiments indicate that the Gaussian copula model has advantages over the empirical copula method in the context of drought severity assessment: (i) it is able to quantify droughts outside the range of the empirical copula, (ii) provides adequate drought quantification, and (iii) provides a better understanding of the uncertainty in the estimation.
While neither criticism is limited to our study, we have tried to investigate the importance of our findings by putting them in the context of disease severity and clinical manifestation.
The association between polytherapy exposure and higher rates of malformations should be considered in the context of the small sample size, severity of the baseline disorder that required polytherapy, associated comorbidities, as well as any other unknown environmental factors that were not assessed in this study.
On the other hand, the scores of the industry group were markedly higher for several criteria, particularly criteria of the clusters 'Context of intervention' (Disease severity: +0.2, Size of population: +0.2), 'Intervention outcomes' (Improvement of efficacy: +0.2, Improvement of safety: +0.2, Improvement of PRO: +0.2), and 'Budget impact' (+0.4).
As such, our findings require further exploration in the context of a validated severity of illness system.
Whether elevated sIgG4 levels, in this context, are a cause or consequence of the severity of PSC remains elusive.
Given the exploratory nature of the study, prospective work tracking GI and emotional symptom severity in the context of the menses phases will be important as a next step.
