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Even in such a case, a genuine ortholog can typically be found among the inparalogs by examining the context of the alignment path (nodes 2.1 and 2.2 in Figure 10C3).
For example, it may be useful for inspecting their proteins of interest in the context of the alignment of their evolutionary families, secondary structure, solvent accessibility states and the likelihood of implied residue residue interactions (as computed by QMEAN).
The differing length-dependent dispersions of Λ for coding and non-coding regions suggest that a better classification rule could be obtained by interpreting the log-likelihood ratio for each example in the context of the alignment's length.
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However, the genomic context and the alignment of this sequence with the PrdC of several clostridial species show that this selenoprotein (RnfC) is actually PrdC.
And such error causes severe interference, especially in the context of signal alignment transmissions, where the incompletely removed self-interference, an unique phenomenon for signal alignment, will severely degrade the transmission reliability.
In addition to the seven tetrapod and five teleost species listed in Additional file 1, Table S1, we selected 16 additional species to study periostin exon 21V22 in the context of an alignment of genomic sequences containing the periostin locus.
An sci close to 1 indicates perfect structure conservation, while alignments without structural conservation yield values close to 0. A more detailed discussion of the sci can be found in [ 16] in the context of RNA alignment.
Tree-decomposition-based algorithms have been successfully applied in the area of computational biology, for instance, in the context of structure sequence alignment [ 17].
In the context of alignment concatenation, however, the problem becomes acute, since no single model can subsume all genes simultaneously, and model misspecification is more or less guaranteed.
Experiments demonstrate that applying PSO in the context of ontology alignment is a feasible approach.
RIC is used in the context
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com