Fluctuations of conserved interactions between the enzyme and RNA substrate, as well as the dynamics of conserved active site residues, are examined and discussed in the context of step 3 of the religation mechanism.
With the model so developed, analysis of the network of interactions mediated by the presence of the divalent magnesium, as well as the proximity of the cation to the AppN substrate, suggests possible functional roles for the bound metal in the context of step 3 chemistry.
This statement will be addressed later in greater detail in the context of step-size bounds for stability.
Symptom-based EOPs, however, could place a workload on operators because they have to not only identify related symptoms, but also understand the context of steps that should be carried out.
In the context of stepped care, this issue is addressed by providing more-intense treatment options to higher affected patients [ 25].
In this regard, BDD-NET may be particularly useful in the context of stepped care for BDD, where low-risk patients with reasonably good insight are offered ICBT and non-responders or more complex and risky patients are offered more intensive, clinic-based CBT alone or in combination with medication.
We first introduce the EXPRESS language, developed within the context of the STEP project (officially ISO 10303), for modeling highly structured industrial data.
DNA conformation could also be understood in the context of base step or helicoidal parameters [38].
Their findings illustrate the potential importance of the Mediterranean dietary pattern compared with other recommended diets, within the context of a Step–I (ie, total fat <30% of total calories, carbohydrates >55% of total calories, protein about 15% of total calories and cholesterol <300 mg/dl).
From the patient's perspective, there is evidence that self-monitoring, on its own, is a therapeutic activity via increasing self-awareness [ 23], particularly of one's emotions, and leading to positive behaviour change [ 24- 26], and therefore in the context of first step mental health care in primary care settings may lead to therapeutic outcomes.
The Fed would have an opportunity to discuss this in its upcoming policy meetings in the context of evolutionary steps to strengthen its forward policy guidance, an initiative that Yellen has spearheaded.
