Sentence examples for context of replication from inspiring English sources

However, in the context of replication, it remains unlikely to detect an effect due to statistical fluctuation only.

Activation of the strict late viral UL38 gene is dependent upon preceding sequential activation of immediate early and early viral genes and cellular transcription factors [17] and the UL38 promoter (UL38p) has been demonstrated to be selectively activated in cancer cells in the context of replication competent γ134.5−/− HSV mutants [18].

Therefore, modulation of nucleotide metabolism might be beneficial for nDNA maintenance in the context of replication stress conditions, which reduce dNTP availability (Lopez-Contreras et al, 2015).

These ultrafine Bloom-containing bridges form in the context of replication stress by linking sister chromatids at fragile sites that carry intrinsic difficulties to replicate (Chan et al, 2009; Sfeir et al, 2009; Barefield & Karlseder, 2012).

Intriguingly, the suppression of genome instability in the context of replication stalling amid dysfunctional SMC-5/ 6 suggests that the maintenance of familial BRCA1 carrier mutations might confer selective advantages under certain conditions of genotoxic challenges.

In RNase H2-deficient strains, rNMP incorporated into the leading strand can be removed by processing outside the context of replication in a process that requires Top1 and repetitive sequences and gives rise to misaligned intermediates, resulting in short deletions (Clark et al. 2011; Kunkel 2011; Miyabe, Kunkel and Carr 2011).

Furthermore, codon and promoter optimizations can greatly enhance the overall immunogenicity of spike protein in the context of replication-defective human and simian adenoviral vaccine carriers.

This is achieved through transcriptional regulation of the gene of interest in a cell cycle-dependent manner, which has been shown to work well in the context of replication-deficient HSV-1 amplicon vectors (Ho et al, 2004; Wang et al, 2007; Ho et al, 2010; Sia et al, 2013).

In the present study, we were able to discern the distribution of replication-associated proteins, in the context of DNA replication, at the level of individual cells.

When mutations begin to affect the zones responsible for one of the four anticancer fail-safes, the cells are no longer simply sabotaged or 'manipulated' by a pathogen within the context of its replication strategy, they are considered genetically cancerous: neither the host nor the pathogen have control over the cells' anarchic replication.

These findings contribute toward our understanding of micro-foundations of capability evolution in the context of a replication strategy, by uncovering the dual workings of organizational context elements in both enabling and challenging middle managers' knowledge search actions.