Donor CD8+ T cells are activated when their T-cell receptor (TCR) binds to recipient peptides presented in the context of recipient class I major histocompatibility complex (MHC) molecules (see Box 1 for a glossary of immunological terms).
Instead, the injected DC were short-lived, internalized as apoptotic cells by recipient's quiescent CD11chi DC in the spleen, which presented the donor allopeptides in the context of recipient's MHC molecules to indirect pathway T cells.
However, different laboratories [ 123– 125] have independently shown that the DST effect requires presentation of donor allopeptides in the context of recipient's MHC molecules to anti-donor T cells via the indirect pathway.
We have to reiterate from the beginning (line 6) because the current context of the recipient may have changed since the last time the propagate function was called.
We propose an adaptable middleware, called Radiator, where context propagation is controlled by functions that, given the context of the recipient, dictate in which conditions a given context message should be propagated.
However, cells and genes do not operate independently of their environment, but always in the context of the recipient.
It was also suggested that the provision of feedback must be adaptable and personalised towards the specific personal and environmental context of the recipient.
Maintenance of the foreignness of a laterally transferred gene in the context of its recipient genome could reflect either a recent transfer event or a selective pressure to maintain certain features.
Analysis in the context of donor and recipient (D/R) CMV serostatus showed that, consistent with the established hierarchy of risk, the majority of D+R− patients developed viremia and required treatment (viremia: 58/74, [78%]; treatment: 51/74, [69%]).
Therefore carriage of Chlamydia in the peripheral circulations could be significant in the context of transfusion or transplant recipients as well as routine health assessments.
