The use of a cut-off threshold of 1.5 on the fold-change is not uncommon in the context of miRNA profiling studies [84]-[86 [84]-[86
KB and VS contributed to the study design, interpreting the results in the context of immune profiling, and drafted and reviewed the manuscript.
The benefits of our framework are exemplarily shown in the context of phylogenetic profiling of transcription factor binding sites and detection of microRNAs close to transcription start sites of our gene set.
Beyond this obvious use, this index can also be used to derive a weighting scheme that introduces the idea of non-discrete functional modules within the context of functional profiling methodologies in a straightforward manner.
Cornerstone of therapy remains radiation and alternative strategies like interstitial radiosurgery, chemotherapy or antiangiogenic drugs need to be further explored, ideally in the context of molecular profiling for common alterations such as 1p/19q codeletion, MGMT promoter methylation and IDH mutation.
Given the current social context of racial profiling, growing inequities, and media hype, the potential harms associated with racial and ethnic categorization cannot be ignored (Varcoe et al. 2009).
However, the reduced number of features (compared with the number of genes measured within a gene expression microarray) raises some doubts about the appropriateness of such methods in the context of miRNA profiling, and new strategies have been proposed, such as a modified least-variant set normalization for miRNA microarray [ 62].
It is the first study conducted in Italy with the specified aim of comparing the performance of risk-adjustment models with and without clinical variables and drugs prescription information in the context of hospital profiling and comparative outcomes research in general.
Although personal genome testing implies its own potential societal risks, there is at least one such risk that has always been paramount to the ELSI-debate on clinical genetic testing, but that lacks ground in the context of genetic profiling for multifactorial diseases: the risk of discrimination or stigmatization.
