Sentence examples for context of mutations from inspiring English sources

Furthermore, even in the context of mutations in the breast cancer susceptibility genes BRCA1 and BRCA2, high rates of p53 mutation are found [ 5, 6].

(C ) Sequence context of mutations at GC pairs in diploid yeast genomes (indicated as mutations at cytosines) exposed to AID*, sA3G* or EMS mutagenesis.

DOI: http://dx.doi.org/10.7554/eLife.02001.014 10.7554/eLiFigure01.015 Figure 3 figure supplement 4. Dinucleotide context of mutations induced by the restoration of bottom strand lesions on FM1.

DOI: http://dx.doi.org/10.7554/eLife.02001.011 10.7554/eLiFigure01.012 Figure 3 figure supplement 1. Dinucleotide context of mutations induced by the restoration of the indicated lesion generated by reconstituting the FM1 episome on the top strand with the indicated oligonucleotides.

Axonal swellings and transport organelle accumulations are commonly observed in mammalian models of AD (Stokin et al., 2008), and 'traffic jams' have been reported in Drosophila axons in the context of mutations that disrupt axonal transport (Gunawardena and Goldstein, 2001).

Overall, our study points to short or dysfunctional telomeres as the primary cause of pathology in human cases of DC in the context of mutations in DKC1, TERC and TERT.

In this last case, signs of CD were subtle and were diagnosed only in the context of mutation analysis.

Moreover, these data suggest that SpeB loss, only in the context of mutation of the covR/S regulatory circuit, promotes invasion.

We denote the mutation context of mutation mut in position pos of the word W as { mut | pos, W}.

The second type of experiment looks at the performance of the tools in the context of mutation database curation.

Both the KJ effect [ 8] and the Fisher effect [ 12] can arguably be considered within the wider context of mutation and selection, even though Fisher's argument was not couched in mathematical terms.