Even in the context of linkage clustering, one can vary between the extremes of single linkage and complete linkage (see overviews in, e.g., [23], [24]).
In this article, we will frame a general statistical model for estimating the linkage between different SNPs and testing haplotype effects within the context of linkage disequilibrium analysis in an F2 pedigree.
In particular, Risch (1990) considered two different models for the manner in which multiple genes act together to influence risk of a complex disease trait and explored their implications in the context of linkage analysis.
This problem was introduced to the human genetics literature by Göring et al. [2001] in the context of linkage analysis, and was further elucidated for genomewide association scans by Garner [2007].
However, when these studies consider consent requirements in the context of data linkage [ 6, 10– 12], data linkage research sometimes appears as one of many scenarios presented in the general health research context and has not been focused on exclusively.
The training content was informed by the scoping study findings and sought to provide participants with the necessary foundations of data linkage methodology and the skills required to assess the principal ethical concerns in the context of data linkage.
This novel approach identifies and accommodates conditional dependence in the context of record linkage.
As shown in the context of modeling linkage disequilibrium [ 40], various graph structures can be used to represent sets of discrete random variables, such as genotypes.
Furthermore, by scoring CNVs in the context of their linkage relationships we were able to discover complex subclasses of CNVs (Additional file 100 Additional file 11).
As a result, little is known about lay people's views and their preferences about consent requirements in the context of data linkage.
As a result, little is known about lay people's views and their preferences about consent requirements in the context of data linkage [ 17].
