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Thus the ecological orientation commits immunologists to examine not only the internal systems of immunity as traditionally conceived, but also to address the challenge of defining the immune system in the full context of its environment and the commune of individuals comprising the species.
We present a Bayesian framework for ToM-based plan recognition, expressing generative models of belief- and desire-dependent planning in terms of partially observable Markov decision processes (POMDPs), and reconstructing an agent's joint belief state and reward function using Bayesian inference, conditioned on observations of the agent's behavior in the context of its environment.
Microenvironment considerations have become a large field of interest in life science; no given cell type can be comprehensively considered without the context of its environment.
The outcomes from the multi-agent model were strongly dependent on the control strategies deployed and the spreading characteristics of the epidemic in the context of its environment.
Consideration of these factors along with the whole animal in the context of its environment can only advance the science, perhaps provide clues to the causative pathways of skin ulcers in fish, and give us keener insight into the health of the aquatic environment.
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Recent developments in flow cytometry and next-generation sequencing technologies have led to major discoveries over the past few years, providing a more integrated understanding of the developing human immune system in the context of its microbial environment.
With evidence of an SL-1 induced transcriptional response in immune cells, we decided to evaluate the role of SL-1 during pathogenesis in the context of its natural environment, the Mtb cell envelope.
To evaluate the role of SL-1 in the context of its native environment, the Mtb cell envelope, we engineered a strain of Mtb in which SL-1 biosynthesis is abolished at its first committed step, sulfation of trehalose by the sulfotransferase Stf0 (see entire pathway elaborated in Supplementary Figure 1).
Thus, we created an Erdman strain of Mtb completely lacking SL-1 (Δ stf0), by deletion of the enzyme involved in the first committed step of SL-1 biosynthesis, to probe the role of SL-1 during host pathogenesis in the context of its natural environment: the Mtb cell envelope.
A dene thus captures something tangible about what the organism inherently is, and a bene captures something about what it does, or what it is capable of doing, always of course in the context of its internal and external environment.
"I want an impact on the whole child, since you can't separate out a child's organ functions from the rest of his body and the context of his environment".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com