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Therefore, a possible role for miR-16 in the context of differentiation may be associated with cell cycle control in downregulating the proliferation potential of differentiating cells.
In the context of differentiation, one mutation may favor the amplification of granulo-monocytic progenitor, which drives the transformation into acute myeloid leukemia.
Nelson and Nusse (2004) [4] provided a conceptual framework for intersection of these β-catenin pools in the context of differentiation and development.
We further demonstrated the induction of ENO1 in the context of differentiation and alveolar epithelial injury in ATII cells.
Although autophagic pathways are essential to developmental processes, many questions still remain regarding the initiation signals that regulate autophagy in the context of differentiation.
In addition to this differentiation block, we observed a negative effect of AK2 knockdown on cell survival and proliferation in the context of differentiation.
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The present review provides a global perspective on the structure and function of PNPase and then focuses on hPNPaseold-35 in the contexts of differentiation and senescence.
Our study provides the first detailed description of temporal, bivalent DNA methylation and Polycomb silencing of a known (ES cell) differentiation gene in the context of tumor differentiation and progression.
In a natural context, reversal of differentiation almost never occurs and when it does, can lead to disease and particularly the generation of cancers.
The methylomes represent 6 biological cohorts, demonstrating robust detection of differentially methylated regions (DMRs) in the context of both differentiation and, more subtly, a gene KO system, in this case Tdg.
Consequently, we believe that it is more beneficial to apply DyNB without the informative prior distribution because, e.g. in the context of Th17 differentiation only a fraction of genes respond to the differentiation.
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