This analysis indicated that the essentiality of B was highly specific to cell lines harbouring gene A deficiency, and hence B is synthetic lethal in the context of deficiencies in DDR genes.
Furthermore, these lesions resulted in mitochondrial dysfunction (Leung et al. 2013) that was exacerbated in the context of deficiencies in some mitochondrial fusion, fission, and autophagy proteins (Bess et al. 2012, 2013).
Also, the importance of repair of single-strand DNA breaks, especially in the context of deficiencies in homologous recombination, is well recognised, and targeting this pathway has been shown to increase the response of head and neck cancer cells to radiation in vitro and in vivo [11].
In the context of insulin deficiency, the lack of adiponetin aggravates the lipoatrophy and hyperlipidemia to lethal levels.
Collectively, these data indicate that Pax3 is a brainstem-specific marker of mouse PDGF-B-driven glioma in the context of Ink4aARF-deficiency, p53-deficiency, as well as H3.3-K27M H3.3-K27Mn.
Likewise, menthol exposure was evaluated in the context of G6PD deficiency, such that infants who were neither enzyme deficient nor exposed to menthol were the "grand" referent group to which all others were compared.
Distinct expression patterns between shoot and root have been previously noted for SULTR2 1 in the context of sulfate deficiency [ 13, 23] and further extended in the present study to Pi deficiency.
However, the importance of Gadd45a in regulating HSC stress responses in the context of ATM deficiency is still unknown.
In conclusion, Gadd45a serves as an important regulator in maintaining HSC self-renewal capacity and mitigating hematopoietic malignancy in the context of ATM deficiency.
This particular commercially obtained subline of C57BL/6 mice also exhibits several striking immune phenotypes that have been previously described in the context of Dock2 deficiency.
